International Network of VENous Thromboembolism Clinical Research Networks

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Fostering International VTE Research Collaboration

INVENT-VTE seeks to improve the care of patients affected by venous thromboembolism (VTE) around the world through the design, development, conduct and promotion of high-quality clinical research into the causes, prevention, diagnosis and optimal management of VTE.

99
Countries Involved
99
Funding Opportunities
99
Endorsed Studies

Endorsed Studies

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TILE

Tinzaparin Lead-In to Prevent the Post-Thrombotic Syndrome

Sponsor:

Sunnybrook Health Sciences Centre

Toronto, Canada   

Current Participant(s):

Canada, France,

Status:

  • Seeking sites and collaborators

Lead Network:

CanVECTOR

PLATO-VTE

Platelet mRNA profiling to detect occult cancer in unprovoked venous thromboembolism

Sponsor:

Academic Medical Center

Amsterdam, the Netherlands

Current Participant(s):

Belgium, Canada, Germany, Italy, Spain, The Netherlands, USA,

Status:

  • Recruitment Completed
  • Analyzing Results

Lead Network:

DTN

RIVASVT-100

Treatment of portal, mesenteric, and splenic vein thrombosis with rivaroxaban. A pilot, prospective cohort study

Sponsor:

Università degli Studi dell'Insubria

Varese, Italy

Current Participant(s):

Canada, France, Germany, Italy,

Status:

  • Recruited started 2015

Lead Network:

TRIP

VERDICT

Venous thromboembolism in renally impaired patients and direct oral anticoagulants

Sponsor:

Centre Hospitalier Universitaire de Saint Etienne

Saint Etienne, France

Current Participant(s):

Canada, France, Serbia, Spain, Switzerland,

Status:

  • Seeking sites and collaborators

Lead Network:

INNOVTE

RENOVE

REduced dose versus full-dose of direct oral anticoagulant after uNprOvoked Venous thromboEmbolism. The RENOVE open-label, randomized, controlled trial

Sponsor:

Brest University Hospital

Brest, France

Current Participant(s):

France,

Status:

  • Seeking sites and collaborators

Lead Network:

INNOVTE

SAVER

Statins for Venous Event Reduction in Patients with Venous Thromboembolism

Sponsor:

Ottawa Hospital Research Institute

Current Participant(s):

Canada,

Status:

  • Pilot trial recruitment completed in Canada and Norway
  • Secured Funding to Begin Full Trial

Lead Network:

CanVECTOR

THEIA

Advanced diagnostic management of suspected recurrent ipsilateral deep vein thrombosis of the leg with magnetic resonance direct thrombus imaging

Sponsor:

Leiden University Medical Center

Current Participant(s):

Canada, Norway, Sweden, The Netherlands,

Status:

Lead Network:

DTN

HIGHLOW

Low-molecular-weight heparin to prevent recurrent VTE in pregnancy: a randomized controlled trial of two doses

Current Participant(s):

Belgium, Canada, France, Ireland, Norway, The Netherlands, USA,

Status:

  • Recruitment Completed
  • Analyzing Results

Lead Network:

DTN

ALIFE2

Anticoagulants for living fetuses in women with recurrent miscarriage and inherited thrombophilia

Current Participant(s):

Belgium, Canada, The Netherlands, USA,

Status:

  • Recruiting
  • Seeking sites and collaborators

Lead Network:

DTN

PEITHO-III

A reduced dose of thrombolytic treatment for patients with intermediate high-risk acute pulmonary embolism

Sponsor:

Hopital Européen Georges Pompidou, Assistance Publique Hopitaux de Paris, Université Paris Descartes

Current Participant(s):

Belgium, Canada, France, Germany, Italy, Poland, Romania, Spain, The Netherlands,

Status:

  • Seeking sites and collaborators

Lead Network:

INNOVTE

Pilot PARTUM

Postpartum Aspirin to Reduce Thromboembolism Undue Morbidity

Sponsor:

University of Calgary

Current Participant(s):

Canada, The Netherlands, USA,

Status:

Planning to begin recruitment in January 2020

Lead Network:

CanVECTOR

ADJUST-DVT

Age-adjusted d-dimer cutoff levels to rule out deep vein thrombosis

Sponsor:

University Hospital

Geneva, Switzerland

Current Participant(s):

Canada, Switzerland,

Status:

  • Recruiting 
  • Seeking sites & collaborators 

Lead Network:

INNOVTE

REDUCE

Management of recurrent venous thromboembolism during anticoagulant treatment in cancer patients - a prospective cohort study

Sponsor:

Amsterdam University Medical Center

Amsterdam, the Netherlands

Current Participant(s):

Italy, The Netherlands,

Lead Network:

DTN

Rhea 

Optimizing diagnosis of splanchnic vein thrombosis with MR direct thrombus imaging

Sponsor:

  • The Netherlands: Dutch Thrombosis Network  (Leiden University Medical Center, Leiden; Erasmus Medisch Centrum, Rotterdam)
  • Italy: Thrombosis Research Italian Partnership (Varese University Hospital, Varese)

Current Participant(s):

Italy, The Netherlands,

Lead Network:

DTN

COBRRA

Comparison of Bleeding Risk Between Rivaroxaban and Apixaban for the Treatment of Acute Venous Thromboembolism

Sponsor:

OHRI (Ottawa Hospital Research Institute)

Current Participant(s):

Australia & New Zealand, Canada,

Lead Network:

CanVECTOR

REMAP-ATTACC

Antithrombotic Therapy to Ameliorate Complications of COVID-19

Sponsor:

University of Manitoba

Collaborator: University Health Network, Toronto

Current Participant(s):

Canada,

Status:

No longer recruiting

Lead Network:

CanVECTOR

RAPID COVID COAG

Coagulopathy of COVID-19: A Pragmatic Randomized Controlled Trial of Therapeutic Anticoagulation versus Standard Care as a Rapid Response to the COVID-19 Pandemic

Sponsor:

St. Michael's Hospital, Toronto

Collaborator: University of Vermont Medical Center

Current Participant(s):

Canada, The Netherlands, USA,

Status:

Recruiting 

Lead Network:

CanVECTOR

SAFE-SSPE

Clinical Surveillance vs. Anticoagulation For low-risk patiEnts with isolated SubSegmental Pulmonary Embolism: a multicenter randomized placebo-controlled non-inferiority trial

Sponsor:

Inselspital, Bern University Hospital, University of Bern

Current Participant(s):

Canada, Switzerland, The Netherlands,

Status:

Recruiting 

Lead Network:

DTN

MEDEA

Heavy MEnstrual bleeding in premenopausal women treated with DirEct oral Anticoagulants

Sponsor:

Amsterdam University Medical Center

Current Participant(s):

Ireland, The Netherlands,

Status:

Recruiting

Lead Network:

DTN

Determinants and Impact of the Post- Venous Thromboembolism (VTE) Syndromes

Determinants and Impact of the Post- Venous Thromboembolism (VTE) Syndromes

Sponsor:

Leiden University Medical Center, Leiden, The Netherlands.

Current Participant(s):

Canada, Ireland, The Netherlands,

Lead Network:

DTN

LEaD

Safely Ruling out Deep Vein Thrombosis in Pregnancy with the LEFt Clinical Decision Rule and D-dimer

Sponsor:

Current Participant(s):

Canada, Switzerland, The Netherlands,

Status:

  • Recruiting
  • Seeking new sites and collaborators 

Lead Network:

CanVECTOR

Real-World Use of DOACs in Children: An International Registry

Real-World Use of DOACs in Children: An International Registry

Sponsor:

  • Children’s Hospital of Philadelphia
  • University of Amsterdam

Current Participant(s):

The Netherlands, USA,

Lead Network:

VENUS

                                                                                                               

                                                                                                                                          

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