Endorsed Studies

The following studies are endorsed by the Network after undergoing a review and approval process established by the Network to identify high-quality studies that address important unanswered clinical questions about venous thromboembolism. The formal review process provides a mechanism for INVENT Council Members to jointly determine which studies the network will promote and support. Learn about each study below.

Endorsed Studies

Recruiting Studies

TILE

Tinzaparin Lead-In to Prevent the Post-Thrombotic Syndrome

VERDICT

Venous thromboembolism in renally impaired patients and direct oral anticoagulants

RENOVE

REduced dose versus full-dose of direct oral anticoagulant after uNprOvoked Venous thromboEmbolism. The RENOVE open-label, randomized, controlled trial

SAVER

Statins for Venous Event Reduction in Patients with Venous Thromboembolism

PEITHO-III

A reduced dose of thrombolytic treatment for patients with intermediate high-risk acute pulmonary embolism

Pilot PARTUM

Postpartum Aspirin to Reduce Thromboembolism Undue Morbidity

ADJUST-DVT

Age-adjusted d-dimer cutoff levels to rule out deep vein thrombosis

REDUCE

Management of recurrent venous thromboembolism during anticoagulant treatment in cancer patients - a prospective cohort study

Rhea

Optimizing diagnosis of splanchnic vein thrombosis with MR direct thrombus imaging

COBRRA

Comparison of Bleeding Risk Between Rivaroxaban and Apixaban for the Treatment of Acute Venous Thromboembolism

SAFE-SSPE

Clinical Surveillance vs. Anticoagulation For low-risk patiEnts with isolated SubSegmental Pulmonary Embolism: a multicenter randomized placebo-controlled non-inferiority trial

MEDEA

Heavy MEnstrual bleeding in premenopausal women treated with DirEct oral Anticoagulants

Determinants and Impact of the Post- Venous Thromboembolism (VTE) Syndromes

Determinants and Impact of the Post- Venous Thromboembolism (VTE) Syndromes

LEaD

Safely Ruling out Deep Vein Thrombosis in Pregnancy with the LEFt Clinical Decision Rule and D-dimer

Real-World Use of DOACs in Children: An International Registry

Real-World Use of DOACs in Children: An International Registry

DAYS

A pilot study to assess feasibility of evaluating the safety and efficiency of a simplified diagnostic approach for deep vein thrombosis

API-CALF

Apixaban to treat calf vein thrombosis

HYDRA

Safety and efficiency of the YEARS algorithm versus computed tomography pulmonary angiography alone for suspected pulmonary embolism in patients with malignancy

PREP and GO

A prospective cohort study evaluating peripartum anticoagulation management among pregnant women with VTE and its impact on patient outcomes

SPECTACULAR

Comparison of 3 Diagnostic Strategies of PE: Planar V/Q Scan, CTPA, and V/Q SPECT

Completed Recruitment

PLATO-VTE

Platelet mRNA profiling to detect occult cancer in unprovoked venous thromboembolism

THEIA

Advanced diagnostic management of suspected recurrent ipsilateral deep vein thrombosis of the leg with magnetic resonance direct thrombus imaging

HIGHLOW

Low-molecular-weight heparin to prevent recurrent VTE in pregnancy: a randomized controlled trial of two doses

REMAP-ATTACC

Antithrombotic Therapy to Ameliorate Complications of COVID-19

ALIFE-2

Anticoagulants for living fetuses in women with recurrent miscarriage and inherited thrombophilia

RAPID COVID COAG

Coagulopathy of COVID-19: A Pragmatic Randomized Controlled Trial of Therapeutic Anticoagulation versus Standard Care as a Rapid Response to the COVID-19 Pandemic

RIVA-SVT 100

Treatment of portal, mesenteric, and splenic vein thrombosis with rivaroxaban. A pilot, prospective cohort study

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